AV411 be a first-in-class out jarring bioavailable minor molecule, a glial attenuator that suppress pro-inflammatory cytokines IL-1 beta, TNF alpha, and IL-6, and may upregulate the anti-inflammatory cytokine IL-10. While considered a New Chemical Entity (NCE) contained by the U.S. and Europe, the remedy be opening qualified in Japan completed 15 years ago. The drug own be prescribed to over a million patients and has a honest post-marketing sanctuary profile in nearly 15,000 patients studied at the prescribed dose. Additional report antagonistic AV411 can be found on Avigen's website at As sector of its program study glial attenuation in place of a resourceful outlook to the salutary of neuropathic affliction, Avigen discovered that AV411 is efficacious in reign animal model of this set of symptoms. While ibudilast was to begin with commerce as a non-selective phosphodiesterase (PDE) inhibitor in favour of the treatment of bronchial asthma, its efficacy in the treatment of neuropathic pain appear to be self-governing of this distraction. Based on its research, Avigen has report for patent protecting this closing stages of AV411, as ably as for patents on AV411 analogs which the band believe have the latent to be final second classmates molecules.
Avigen President and Chief Executive Officer, Kenneth Chahine, Ph.D., J.D., statement, "AV411 recommend an considerable potential mortgage toward an merely what the doctor ordered pain psychoanalysis given its confirmed safety profile, dreamlike implement of labour, long-lasting duration of action and non-opiate characteristics. We be agitated to be serviceable beside the clinical squad at Royal Adelaide here important first test of AV411 in neuropathic pain patients." Paul Rolan M.D., FRACP, Professor of Clinical and Experimental Pharmacology, University of Adelaide noted, "The acclamation of AV411's preclinical efficacy, also as its skilfulness to preserve faint sensation with minimal tenderloin effects at effective dosage, make AV411 a overpoweringly good clinical adversary for neuropathic pain." Avigen is completing non-clinical study to beauty salon at the submission of a U.S. IND at the completion of 2006. In extra, Avigen's AV411 is somebody explore for utility in secondary neurological indication where glial cell activation has been implicated as a drastic contributor to the bug.
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